Electrochemical investigations of unexplored anthraquinones and their DNA binding

  • Afzal Shah Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
  • Abdur Rauf Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
  • Asad Ullah Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
  • Azeema Munir Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
  • Rumana Qureshi Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
  • Iftikhar Ahmad Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
  • Muhammad Tahir Soomro Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
  • Zia-Ur Rehman Azam University, 45320, Islamabad, Pakistan and National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro

Abstract

The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin.

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Published
06-02-2013
Section
Bioelectrochemistry & Fuel Cells