Electrochemical sensor for determination of hydroxylamine using functionalized Fe3O4 nanoparticles and graphene oxide modified screen-printed electrode

Original scientific paper

  • Hamed Tashakkorian Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Iran and Department of Pharmacology, School of Medicine, Babol University of Medical Sciences, Babol, Iran 3Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
  • Behnaz Aflatoonian Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
  • Peyman Mohammadzadeh Jahani School of Public Health, Bam University of Medical Sciences, Bam, Iran
  • Mohammad Reza Aflatoonian Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
Keywords: hydroxylamine, electroanalysis, voltammetry, modified electrode
Graphical Abstract


A simple strategy for determination of hydroxylamine based on Fe3O4 nanoparticles function­nalized by [2-(4-((3-(trimethoxysilyl)propylthio)methyl)1-H1,2,3-triazol-1-yl)acetic­acid] (FNPs) and graphene oxide (GO) modified screen-printed electrode (SPE), denoted as (Fe3O4 FNPs/GO/SPE), is reported. The electrochemical behavior of hydroxylamine was investigated at Fe3O4FNPs/GO/SPE by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chro­noamperometry (CHA) techniques in phosphate buffer solution (pH 7.0). Fe3O4 FNPs/GO/SPE as a novel electrochemical sensor exhibited catalytic activity toward the oxidation of hydroxyl­ami­ne. The potential of hydroxylamine oxidation was shifted to more negative potentials, and its oxidation peak current increased on the modified electrode, also indicating that under these conditions, the electrochemical process is irreversible. The electrocatalytic current of hydroxyl­amine showed a good relationship in the concentration range of 0.05–700.0 μM, with a detection limit of 10.0 nM. The proposed electrode was applied for the determination of hydroxyl­amine in water samples, too.


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